Name: Hotel Museo Spa Casa Santo Domingo
Price range: $331 total
Rating: 9.2

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Your Central Highlands Vacation

Leave all the planning up to us with a Central Highlands vacation package. With everything organized before you depart, all you need to do is sit back, chill out and enjoy this destination's culture and charm. Your trip to Central Highlands wouldn't be complete without spending some time in its most renowned cities, starting with Guatemala City. A couple of the top attractions here include Paseo Cayala and La Aurora Zoo. Chiquimula is another favorite city with Central Highlands travelers. Visitors to this destination enjoy Ismael Cerna Park and Nuestra Senora del Transito Church. Expedia is your one-stop shop when it comes to planning your Central Highlands vacation. From hotels and flights, to activities and more, we know how to curate a travel experience like no other.

The Latest Central Highlands vacation packages

Price found within the past 48 hours. Click for updated prices.

Finca El Tambor

$703

per person

Sep 5 - Sep 12

found 1 day ago

Roundtrip non-stop flight included

Miami (MIA) to Guatemala City (GUA)

9/10 Wonderful! (28 reviews)

Casa Faustina Boutique Hotel

Save 100% on your flight

$730

per person

Sep 9 - Sep 14

found 1 day ago

Roundtrip flight included

Los Angeles (LAX) to Guatemala City (GUA)

8.8/10 Excellent! (118 reviews)

Muy bonito hotel, personal amable, fácil de llegar y precio acorde.

Reviewed on Jul 1, 2026

Hotel Soleil La Antigua

$887

per person

Aug 19 - Aug 25

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)

8.6/10 Excellent! (1,000 reviews)

Pequeños inconvenientes al usar el sauna y spa, tuve que pedir cambio de toalla que se la tuve que pedir a un adolescente la había agarrado y la estaba usando, personas sin traje de baño usando el jacuzzi en ropa interior o pantaloneta. Los baños del spa se mantenían sucios por la cantidad de personas presentes por el finde largo. El primer día esperamos 1hr para que hubieran toallas disponibles.

Reviewed on Jun 29, 2026

Hotel Soleil Pacifico

$819

per person

Sep 16 - Sep 23

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Guatemala City (GUA)

7.2/10 Good! (404 reviews)

Muy cerca de la playa. Las piscinas muy bonitas y grandes.

Reviewed on Jul 3, 2026

Kula Maya Boutique Hotel & Spa

Save 100% on your flight

$824

per person

Sep 17 - Sep 22

found 1 day ago

Roundtrip flight included

Los Angeles (LAX) to Guatemala City (GUA)

9.6/10 Exceptional! (158 reviews)

amazing views!!!! beautiful hotel very clean. the restaurant was wonderful too

Reviewed on Jun 19, 2026

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Where to stay in Central Highlands

Find the best Central Highlands areas and neighborhoods for the activities you enjoy most. Learn more about Central Highlands

A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

4 out of top 10 points of interest in this area

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

Stay near popular Central Highlands attractions

An ancient architectural structure with arched ceilings and columns.

Antigua Guatemala Cathedral

9.4/10 (2,647 reviews)

After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints, or seek out its local tours.

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Central Highlands Hotel Deals

Tikal Futura Hotel & Convention Center

Calzada Roosevelt 22-43 Guatemala City Guatemala

Fully refundableReserve now, pay when you stay

$108 nightly

$132 total

Jul 12 - Jul 13

Total with taxes and fees

9.2/10 Wonderful! (1,001 reviews)

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Reviewed on Jul 2, 2026

Barceló Guatemala City

7 Avenida 15-45, Zona 9 Guatemala City Guatemala

Fully refundableReserve now, pay when you stay

$107 nightly

$131 total

Jul 8 - Jul 9

Total with taxes and fees

9.2/10 Wonderful! (3,292 reviews)

"Un manque flagrant d’entretien des chambres notamment les douches. Le matelas était très affaissé au centre, ce qui nous faisait rouler l’un vers l’autre pendant la nuit."

Reviewed on Jul 3, 2026

Hotel Museo Spa Casa Santo Domingo

3a Calle Oriente No 28 A Antigua Guatemala Sacatepequez

Fully refundableReserve now, pay when you stay

$271 nightly

$331 total

Jul 5 - Jul 6

Total with taxes and fees

9.2/10 Wonderful! (1,071 reviews)

"The air conditioning of the room wasn't that cold but still was a great stay"

Reviewed on Jul 3, 2026

See all 1,321 properties in Central Highlands

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.